2,5-Dichloropyrimidine → HCID 117729441, compound

HRID 61207Notes

Reaction equation

HRID 61207 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[CH:17]=[C:16]([F:18])[C:15]([F:19])=[CH:14][C:13]=1[C:20]1[N:25]=[CH:24][CH:23]=[CH:22][N:21]=1)=[O:11].Cl[C:27]1[N:32]=[CH:31][C:30]([Cl:33])=[CH:29][N:28]=1>>[Cl:33][C:30]1[CH:29]=[N:28][C:27]([NH:1][CH2:2][C@@H:3]2[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]2[C:10]([C:12]2[CH:17]=[C:16]([F:18])[C:15]([F:19])=[CH:14][C:13]=2[C:20]2[N:21]=[CH:22][CH:23]=[CH:24][N:25]=2)=[O:11])=[N:32][CH:31]=1

Participants

3

Reactant 2

HCID 5906412,5-DichloropyrimidineHCID 117727894((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)methanone

Product 1

HCID 117729441HCID 117729441, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A1 using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)methanone and 2,5-dichloropyrimidine. ESI-MS (m/z): 459 [M+1]+.

Sources & evidence

ORD record
ord-e0e1eff6f8a642abbe2bd2adecfef854
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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