HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 612119Generated: October 31, 2026
Iodoethane → Methyl 4-ethoxy-3-methoxybenzoate
https://huagongshe.com/reaction/612119
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl Vanillate | HCID 19844 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 4-ethoxy-3-methoxybenzoate | HCID 592192 | 89.8% |
Reaction Steps
A mixture of 25.0 g (137 mmol) methyl vanillate, 38.87 g (274 mmol) potassium carbonate, 500 ml DMF, and 16.5 ml (206 mmol) ethyl iodide was heated to 100° C. under N2. At 2.5 hours, cooled and removed solids. Stripped solvent, and partitioned between water and methylene chloride. Stripped solvent and dried in vacuo, giving 25.85 g of white solid: mass spectrum (EI m/e): M=210.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06002008 |
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| Source dataset | uspto-grants-1999_12 |
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| ORD ID | ord-32b0b8b26aaf4d6fb2720a564ed87758 |
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| Source note | uspto-grants-1999_12 |
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