2-Chloro-5-(trifluoromethyl)pyrimidine → HCID 117727795, compound

HRID 61212Notes

Reaction equation

HRID 61212 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[CH:17]=[C:16]([F:18])[C:15]([F:19])=[CH:14][C:13]=1[N:20]1[N:24]=[CH:23][CH:22]=[N:21]1)=[O:11].Cl[C:26]1[N:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][N:27]=1>>[F:19][C:15]1[C:16]([F:18])=[CH:17][C:12]([C:10]([N:4]2[CH2:5][CH2:6][CH2:7][C@@H:8]([CH3:9])[C@H:3]2[CH2:2][NH:1][C:26]2[N:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][N:27]=2)=[O:11])=[C:13]([N:20]2[N:24]=[CH:23][CH:22]=[N:21]2)[CH:14]=1

Participants

3

Reactant 2

HCID 133170192-Chloro-5-(trifluoromethyl)pyrimidineHCID 117727872HCID 117727872, compound

Product 1

HCID 117727795HCID 117727795, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A1 using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone and 2-chloro-5-(trifluoromethyl)pyrimidine. ESI-MS (m/z): 482 [M+1]+. 1H NMR (300 MHz, DMSO-d6) δ 8.30-6.85 (m, 7H), 4.90-2.70 (m, 5H), 1.90-0.65 (m, 8H).

Sources & evidence

ORD record
ord-c7dba45e889f43fa8113df2de3a30107
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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