HCID 67116235, compound → HCID 117728206, compound

HRID 61215Notes

Reaction equation

HRID 61215 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1C(C1C=C(C)C=CC=1C1C=NN(C)C=1)=O.[F:25][C:26]1[C:34](F)=[CH:33][C:29]([C:30]([OH:32])=O)=[C:28]([N:36]2[N:40]=[CH:39][CH:38]=[N:37]2)[CH:27]=1>>[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:30]([C:29]1[CH:33]=[CH:34][C:26]([F:25])=[CH:27][C:28]=1[N:36]1[N:40]=[CH:39][CH:38]=[N:37]1)=[O:32]

Participants

3

Reactant 2

HCID 67116235HCID 67116235, compoundHCID 117728145((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

Product 1

HCID 117728206HCID 117728206, compound

Procedure

The title compound was prepared following the same general protocol as described for ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone in Example A1 using 4,5-difluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid. MS (ESI) 318.4 (M+H).

Sources & evidence

ORD record
ord-486f43ab60e2441894a74b23724d54a6
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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