反应详情

To a suspension of 200 mg (0.91 mmol) of -chloro-7-methoxy-3-quinolinecarbonitrile and 135.5 mg (1.10 mmol) of 5-amino-o-cresol in 10 mL of 2-ethoxy ethanol was added 105.6 mg (0.91 mmol) of pyridine hydrochloride. The resulting reaction mixture was refluxed for 1 hr, and then the solvent was removed to give a residue. To the residue was added about 30 mL of water and neutralized to pH 7-8 by addition of diluted sodium carbonate solution. The precipitate was collected by filtration and washed with water and ether. After drying in vacuo, this afforded 277 mg (99%) of the product as a yellow solid, m.p.>250° C., mass (electrospray, m/e): M+H 305.9.

1. customThe resulting reaction mixture
2. temperaturewas refluxed for 1 hr
3. customthe solvent was removed
4. customto give a residue
5. filtrationThe precipitate was collected by filtration
6. washwashed with water and ether
7. customAfter drying in vacuo