4-(Methylthio)aniline → HCID 22466681, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 286, 248.7 mg (1 mmol) of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile in 12 mL of 2-ethoxyethanol and in the presence of 115.6 mg (1 mmol) of pyridine hydrochloride was reacted with 181.0 mg (1.3 mmol) of 4-(methylmercapto)-aniline to give 334.1 mg (95.2%) of the product as a yellow solid, m.p. 235-237° C., mass (electrospray, m/e): M+H 351.9, 352.9, 353.8, 354.9.

Provenance & Evidence