Pyridinium chloride → 4-(4-Chloro-2-fluorophenylamino)-7-hydroxy-3-quinolinecarbonitrile

HRID 612211Notes

Reaction equation

HRID 612211 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:19]C)=[CH:16][CH:17]=3)[N:12]=[CH:11][C:10]=2[C:21]#[N:22])=[C:4]([F:23])[CH:3]=1.Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([OH:19])=[CH:16][CH:17]=3)[N:12]=[CH:11][C:10]=2[C:21]#[N:22])=[C:4]([F:23])[CH:3]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 224666624-(4-Chloro-2-fluorophenylamino)-7-methoxy-3-quinolinecarbonitrile

Product 1

HCID 1356708234-(4-Chloro-2-fluorophenylamino)-7-hydroxy-3-quinolinecarbonitrile

Procedure

In the manner of Example 302 reaction of 4-(4-chloro-2-fluorophenylamino)-7-methoxy-3-quinolinecarbonitrile with pyridine hydrochloride at 210° C. gave the title compound, mp 295-305° C.

Sources & evidence

ORD record
ord-e4d3924f0f424583977919af8f7c5a92
Source dataset
uspto-grants-1999_12
Patent number
US06002008

Reaction notes

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