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Glycol monoethyl ether → 6-Methoxy-4-(2-methylsulfanyl-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Glycol monoethyl ether | HCID 8076 | — |
| 反応物 | 2-(Methylthio)aniline | HCID 76337 | — |
| 反応物 | Pyridinium chloride | HCID 10176127 | — |
| 反応物 | 4-Chloro-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | HCID 22466601 | — |
| 生成物 | 6-Methoxy-4-(2-methylsulfanyl-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile | HCID 22466622 | — |
反応手順
The method of Example 312 was used as well as 0.3 g of 4-chloro-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile, 0.14 ml of 2-(methyl mercapto) aniline, 0.1 g of pyridine hydrochloride and 4.0 ml of 2-ethoxy ethanol. This afforded an oil which was purified by silica gel flash chromatography [methylene chloride/methanol (96:4) ] to give 0.16 g of the title compound as an off white solid, mp 179-180 C; mass spectrum (ES, m/e):M+H465.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06002008 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-f897d461ead4433187de97b977115254 |
| 出典メモ | uspto-grants-1999_12 |