3,4-Difluorobenzylamine → HCID 22466629, compound

HRID 612215Notes

Reaction equation

HRID 612215 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:15][CH2:16][CH3:17])=[C:9]([O:12][CH2:13][CH3:14])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:18]#[N:19].[F:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][C:28]=1[F:29])[CH2:24][NH2:25]>>[F:20][C:21]1[CH:22]=[C:23]([CH2:24][NH:25][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:15][CH2:16][CH3:17])=[C:9]([O:12][CH2:13][CH3:14])[CH:10]=3)[N:5]=[CH:4][C:3]=2[C:18]#[N:19])[CH:26]=[CH:27][C:28]=1[F:29]

Participants

3

Reactant 2

HCID 1235723,4-DifluorobenzylamineHCID 107788724-Chloro-6,7-diethoxyquinoline-3-carbonitrile

Product 1

HCID 22466629HCID 22466629, compound

Procedure

In the manner of Example 61 reaction of 4-chloro-6,7-diethoxy-3-quinolinecarbonitrile with 3,4-difluorobenzylamine gave the title compound as a tan solid, mp167-169° C.

Sources & evidence

ORD record
ord-8c54649d14d248fba8ac432478c4d446
Source dataset
uspto-grants-1999_12
Patent number
US06002008

Reaction notes

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