3'-Aminoacetophenone → HCID 5328847, compound

HRID 612219Notes

Reaction equation

HRID 612219 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]#[N:17].[CH3:18][C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([NH2:27])[CH:22]=1)=[O:20]>>[C:19]([C:21]1[CH:22]=[C:23]([NH:27][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=3)[N:5]=[CH:4][C:3]=2[C:16]#[N:17])[CH:24]=[CH:25][CH:26]=1)(=[O:20])[CH3:18]

Participants

3

Reactant 2

HCID 74173'-AminoacetophenoneHCID 105866764-Chloro-6,7-dimethoxy-quinoline-3-carbonitrile

Product 1

HCID 5328847HCID 5328847, compound

Procedure

In the manner of Example 274 reaction of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile with 3-aminoacetophenone gave the tide compound as a tan solid, mp 204-206° C.

Sources & evidence

ORD record
ord-f05faa0666404e64a35431cfe9b4097e
Source dataset
uspto-grants-1999_12
Patent number
US06002008

Reaction notes

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