2-Methyl-4-methoxyaniline → HCID 22466650, compound

Participants

Reaction Steps

A reaction mixture of 248.7 mg (1 mmol) of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile, 164.6 mg (1.2 mmol) of 4-methoxy-2-methyl-aniline and 115.6 mg (1 mmol) of pyridine hydrochloride in 10 mL of 2-ethoxyethanol was refluxed under N2 for 3 hr. After removal of the solvent, the residue was diluted with water and neutralized to pH 7-8 with diluted sodium carbonate solution. The precipitate was filtered and washed with water and ether. After drying in vacuo, this yielded 250.2 mg (71.7%) of the product as a off red solid, m.p.>131° C(dec.), mass (electrospray, m/e): M+H 349.9.

Provenance & Evidence