3-Amino-2-methylbenzoic acid → HCID 19598401, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 367, 248.7 mg (1 mmol) of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile in 12 mL of 2-ethoxyethanol and in the presence of 115.6 mg (1 mmol) of pyridine hydrochloride was reacted with 196.5 mg (1.3 mmol) of 3-amino-2-methylbenzoic acid to give 89.6 mg (24.7%) of the product as a gray solid, m.p. 242-245° C., mass (electrospray, m/e): M+H 364.0.

Provenance & Evidence