(4-Aminophenoxy)benzene → 6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrile

Participants

Reaction Steps

Using an analogous procedure to that described in Example 367, 248.7 mg (1 mmol) of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile in 12 mL of 2-ethoxyethanol and in the presence of 115.6 mg (1 mmol) of pyridine hydrochloride was reacted with 222.3 mg (1.2 mmol) of 4-phenoxyaniline to give 283.0 mg (71.3%) of the product as a light yellow solid, m.p. 239-241° C., mass (electrospray, m/e): M+H 397.9.

Provenance & Evidence