Benzenamine, 4-chloro-2-methoxy- → HCID 22466616, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 367, 248.7 mg (1 mmol) of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile in 12 mL of 2-ethoxyethanol and in the presence of 115.6 mg (1 mmol) of pyridine hydrochloride was reacted with 189.1 mg (1.2 mmol) of 5-chloro-o-anisidine to give 240.5 mg (65.0%) of the product as a cream solid, m.p. 200-202° C., mass (electrospray, m/e): M+H 369.9, 371.8.

Provenance & Evidence