HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methane → 4-(3-Dimethylaminophenylamino)-6-nitroquinoline-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,3-Benzenediamine, N1,N1-dimethyl-, hydrochloride (1:2) | HCID 77124 | — |
| Reactant | 4-Chloro-6-nitroquinoline-3-carbonitrile | HCID 11085690 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(3-Dimethylaminophenylamino)-6-nitroquinoline-3-carbonitrile | HCID 22466643 | — |
Reaction Steps
Prepared from 5.00 g of 4-chloro-6-nitroquinoline-3-carbonitrile, 5.38 g of 3-dimethylaminoaniline dihydrochloride and 5.17 g of triethylamine in the same manner as Example 377. The crude product was taken up in EtOAc, treated with Darco, filtered through Celite, evaporated and dried in vacuo (50° C.). The yield of 4-(3-dimethylaminophenylamino)-6-nitroquinoline-3-carbonitrile was 5.62 g as brick red crystals: mass spectrum (electrospray, m/e): M+H 334.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06002008 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-6cf226f92135494bbfee969ccc94b8b4 |
| Source note | uspto-grants-1999_12 |