2-methyl-6-(2H-1,2,3-triazol-2-yl)benzoic acid → HCID 117727685, compound

HRID 61231Notes

Reaction equation

HRID 61231 reaction equation
[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[CH:17]=[C:16](C)[CH:15]=[CH:14][C:13]=1[C:19]1C=NN(C)C=1)=[O:11].CC1C=CC=C([N:35]2[N:39]=[CH:38][CH:37]=[N:36]2)C=1C(O)=O>>[NH2:1][CH2:2][C@@H:3]1[C@H:8]([CH3:9])[CH2:7][CH2:6][CH2:5][N:4]1[C:10]([C:12]1[C:17]([N:35]2[N:39]=[CH:38][CH:37]=[N:36]2)=[CH:16][CH:15]=[CH:14][C:13]=1[CH3:19])=[O:11]

Participants

3

Reactant 2

HCID 670869732-methyl-6-(2H-1,2,3-triazol-2-yl)benzoic acidHCID 117728145((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone

Product 1

HCID 117727685HCID 117727685, compound

Procedure

The title compound was prepared following the same general protocol as described for ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone in Example A1 using 2-methyl-6-(2H-1,2,3-triazol-2-yl)benzoic acid. ESI-MS m/z: 314 [M+1]+.

Sources & evidence

ORD record
ord-ba33ac45823645e182ee372eb1dc10e9
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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