2-Bromo-1,1-difluoroethane → HCID 178495000, compound

HRID 612332Notes

Reaction equation

HRID 612332 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15][Si](C(C)(C)C)(C)C)=[C:11]([F:23])[CH:10]=2)=[C:4]([F:24])[CH:3]=1.[CH3:25][O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][Si:32]1(C2C=CC=CC=2)[CH2:37][CH2:36][C:35](=O)[CH2:34][CH2:33]1.Br[CH2:46][CH:47]([F:49])[F:48]>>[CH3:25][O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][Si@H:32]1[CH2:33][CH2:34][C@H:35]([C:2]2[CH:3]=[C:4]([F:24])[C:5]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:46][CH:47]([F:49])[F:48])=[C:11]([F:23])[CH:10]=3)=[C:6]([F:8])[CH:7]=2)[CH2:36][CH2:37]1

Participants

4

Reactant 3

HCID 1361862-Bromo-1,1-difluoroethaneHCID 195938471-(5-Methoxypentyl)-1-phenylsilacyclohexan-4-oneHCID 22373420HCID 22373420, compound

Product 1

HCID 178495000HCID 178495000, compound

Procedure

The general procedure of Example 17 was repeated using 4'-bromo-2', 6'-difluoro-3-fluoro-4-(t-butyldimethylsiloxy)biphenyl, 4-(5-methoxy-n-pentyl)-4-phenyl-4-silacyclohexanone, and 1-bromo-2 ,2-difluoroethane, thereby obtaining the intended compound.

Workup

  1. customobtaining the intended compound

Sources & evidence

ORD record
ord-18a99ffd01ff4b408bdd8ee8409513b0
Source dataset
uspto-grants-1999_12
Patent number
US06004478

Reaction notes

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