Water → 4-(4-(2-(3,5-Difluoro-4-(t-butyldimethylsiloxy)phenyl)ethenyl)cyclohexyl)-1-propyl-1-phenyl-1-silacyclohexane

12.0 g of potassium t-butoxide was added to a mixture of 62 g of 3,5-difluoro-4-(t-butyldimethylsiloxy)benzyltriphenylphosphonium bromide and 200 ml of THF to obtain an orange-colored ylide solution. A mixture of 35.0 g of 4-(4-n-propyl-4-phenyl-4-silacyclohexyl)cyclohexane carbaldehyde in 50 ml of THF was added to the above solution. The mixture was agitated at room temperature for 2 hours, after which it was poured into iced water, followed by extraction with ethyl acetate. The ethyl acetate solution was washed, dried and concentrated by a usual manner. The resultant residue was added to n-hexane and the resultant triphenylphosphine oxide crystals were removed by filtration. The resultant filtrate was concentrated. The residue was purified through silica gel chromatography to obtain 4-(4-(2-(3,5-difluoro-4-(t-butyldimethylsiloxy)phenyl)ethenyl)cyclohexyl)-1-propyl-1-phenyl-1-silacyclohexane. This compound was dissolved in 200 ml of ethyl acetate and hydrogenated in the presence of 200 mg of a platinum oxide catalyst at a hydrogen pressure of 0.1 MPa. After consumption of the theoretical amount of hydrogen, the catalyst was removed by filtration. The resultant filtrate was concentrated. 100 ml of a THF solution of 1 mol/liter of tetrabutylammonium fluoride was added to the concentrate, followed by agitation at room temperature for 3 hours. The reaction mixture was poured into 10% hydrochloric acid, followed by ordinary washing, drying and concentration. The resultant residue was purified through silica gel chromatography. The purified compound was reacted with 24 g of sodium hydride in 12,3-dimethyl-2-imidazolidinone, to which 15 g of 1-bromo-2,2-difluoroethane was added, followed by agitation at 50° C. for 12 hours. The resultant mixture was washed with brine, dried and concentrated by a usual manner. A methylene chloride solution of 1 mol/liter of iodine monochloride was added to the resultant residue and agitated for 1 hour. Thereafter, 10 ml of methanol and 30 ml of triethylamine were added to the solution. After agitation for 1 hour, the mixture was washed, dried and concentrated by a usual manner. The resultant residue was dissolved in 100 ml of THF, to which a solution of 10.0 g of aluminium lithium hydride in 100 ml of THF was added. The reaction mixture was refluxed under agitation for 1 hour. Subsequently, the mixture was poured into 200 ml of 5% hydrochloric acid and extracted with ethyl acetate. After washing, drying and concentration by a usual manner, the extract was purified through silica gel chromatography and then recrystallized to obtain 15.6 g of an intended trans isomer.

1. customto obtain an orange-colored ylide solution
2. additionwas added to the above solution
3. extractionfollowed by extraction with ethyl acetate
4. washThe ethyl acetate solution was washed
5. customdried
6. concentrationconcentrated by a usual manner
7. additionThe resultant residue was added to n-hexane
8. customthe resultant triphenylphosphine oxide crystals were removed by filtration
9. concentrationThe resultant filtrate was concentrated
10. customThe residue was purified through silica gel chromatography

ORD record

ord-7b06595fc31a40fd88e72c205b08270a

Source dataset

uspto-grants-1999_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06004478