4-(t-Butyldimethylsiloxy)benzyltriphenylphosphonium bromide → HCID 178495001, compound

HRID 612336Notes

Reaction equation

HRID 612336 reaction equation
[Br-].[O:2]([C:10]1[CH:35]=[CH:34][C:13]([CH2:14][P+](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[CH:12][CH:11]=1)[Si](C(C)(C)C)(C)C.[CH3:36][O:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][Si:43]1(C2C=CC=CC=2)[CH2:48][CH2:47][CH:46]([CH:49]2[CH2:54][CH2:53][CH:52]([CH:55]=O)[CH2:51][CH2:50]2)[CH2:45][CH2:44]1.Br[CH2:64][C:65]([F:71])([F:70])[C:66]([F:69])([F:68])[CH3:67]>>[F:68][C:66]([F:69])([C:65]([F:71])([F:70])[CH3:64])[CH2:67][O:2][C:10]1[CH:11]=[CH:12][C:13]([CH2:14][CH2:55][C@H:52]2[CH2:53][CH2:54][C@H:49]([C@H:46]3[CH2:45][CH2:44][Si@H:43]([CH2:42][CH2:41][CH2:40][CH2:39][CH2:38][O:37][CH3:36])[CH2:48][CH2:47]3)[CH2:50][CH2:51]2)=[CH:34][CH:35]=1

Participants

4

Reactant 3

HCID 103930914-(t-Butyldimethylsiloxy)benzyltriphenylphosphonium bromideHCID 195938191-Bromo-2,2,3,3-tetrafluorobutaneHCID 540507634-(4-(5-Methoxy-n-pentyl)-4-phenyl-4-silacyclohexyl)cyclohexane carbaldehyde

Product 1

HCID 178495001HCID 178495001, compound

Procedure

The general procedure of Example 38 was repeated using 4-(t-butyldimethylsiloxy)benzyltriphenylphosphonium bromide, 4-(4-(5-methoxy-n-pentyl)-4-phenyl-4-silacyclohexyl)cyclohexane carbaldehyde and 1-bromo-2,2,3,3-tetrafluoro-n-butane, thereby obtaining the intended compound.

Workup

  1. customobtaining the intended compound

Sources & evidence

ORD record
ord-69449da162494eb8a78225541d83bc53
Source dataset
uspto-grants-1999_12
Patent number
US06004478

Reaction notes

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