HuagongsheHuagongshe Chemistry Print Report · For research reference only
EDTA disodium salt → Diclofenac
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | EDTA disodium salt | HCID 8759 | — |
| Reactant | alpha-Tocopherol succinate | HCID 20353 | — |
| Reactant | Emulphor | HCID 5364713 | — |
| Reactant | 2-[2-(2,6-Dichloroanilino)phenyl]acetic acid;diethylazanium | HCID 86754957 | — |
| Solvent | Glycerol | HCID 753 | — |
| Product | Diclofenac | HCID 3033 | — |
Reaction Steps
A diclofenac submicron cream was prepared as follows: Oil phase--diclofenac diethylammonium 12.2 g, MCT oil 170 g, LIPOID E-80 30 g, α-tocopherol succinate 0.4 g; Aqueous phase--EDTA disodium salt 1 g, EMULFOR EL-620 25 g, glycerol 17.5 g, preservatives (methyl and propyl parabens) 0.5 g, reverse osmosis purified water to 1000 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06004566 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-2d9c142721c249ddbbfea422e455589d |
| Source note | uspto-grants-1999_12 |