HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1,3,4-Oxadiazole, 2-phenyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 10968127 | HCID 10968127 | — |
| Reactant | Methoxy-methyl amide | HCID 53630747 | — |
| Reactant | HCID 178418600 | HCID 178418600 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1,3,4-Oxadiazole, 2-phenyl- | HCID 13217 | — |
Reaction Steps
Acetyl-Leu-Leu-OH (133 mg) and arginine (Mtr) -N-methyl-N-methoxy amide (200 mg) were dissolved in 10 mL of DMF and were treated with 243 uL of DIEA and 212 mg of HBTU. The reaction stirred at room temperature for 15 hours and was worked up according to method A. Drying over Na2SO4, rotary evaporation of the solvent and flash chromatography on silica gel (50% acetone in hexane) provided 270 mg of the title compound as a foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06004933 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-59a465c951ce4a20b75bad233928a522 |
| Source note | uspto-grants-1999_12 |