反应详情

Alternatively, a suspension of mucobromic acid (80 g., 310 mmol.) and benzylhydrazine dihydrochloride (60 g., 310 mmol.) in ethanol was heated to reflux for 16 hours. It was cooled to r.t. and under vigourous stirring water (50 mL) was added. The suspension was cooled in an ice bath and then filtered. The solid was washed with 95% aqueous ethanol and air dried. It was swished in hexanes (200 mL) and diethyl ether (25 mL), filtered and air dried to yield the title compound(58 g.).

1. temperaturewas heated
2. temperatureto reflux for 16 hours
3. additionwas added
4. temperatureThe suspension was cooled in an ice bath
5. filtrationfiltered
6. washThe solid was washed with 95% aqueous ethanol and air
7. customdried
8. filtrationdiethyl ether (25 mL), filtered
9. customair dried