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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 61241Generated: October 27, 2026

2-Iodo-3-methylbenzoic acid → ((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanone

https://huagongshe.com/reaction/61241

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Iodo-3-methylbenzoic acidHCID 2759365—
Reactant2-Fluoro-5-(trifluoromethyl)pyridineHCID 5463754—
Reactant((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanoneHCID 117727882—
Product((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanoneHCID 117728000—

Reaction Steps

The title compound was prepared following the same general protocol as described for Example A230 using 2-iodo-3-methylbenzoic acid to make ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanone and 2-fluoro-5-(trifluoromethyl)pyridine. ESI-MS (m/z): 470 [M+1]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09440982B2
Source datasetuspto-grants-2016_09
ORD IDord-efa79bbc0a804747a258041be08104d3
Source noteuspto-grants-2016_09