Acetic Acid → HCID 19595325, compound

HRID 612441Notes

Reaction equation

HRID 612441 reaction equation
[CH2:1]([C:5]1[C:14](=[O:15])[C:13]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[N:7]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[C:24]([C:29]([O:31]C)=[O:30])=[CH:25][CH:26]=[CH:27][CH:28]=3)=[CH:19][CH:18]=2)[CH:6]=1)[CH2:2][CH2:3][CH3:4].[C:33](O)(=O)C>[OH-].[Na+]>[CH2:1]([C:5]1[C:14](=[O:15])[C:13]2[CH2:12][CH:11]([CH3:33])[CH2:10][CH2:9][C:8]=2[N:7]([CH2:16][C:17]2[CH:18]=[CH:19][C:20]([C:23]3[C:24]([C:29]([OH:31])=[O:30])=[CH:25][CH:26]=[CH:27][CH:28]=3)=[CH:21][CH:22]=2)[CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 19595367HCID 19595367, compound

Product 1

HCID 19595325HCID 19595325, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
60 °C

Procedure

Using the procedure of Example 31, 0.4 g of product A of Example 32 in 10 ml of 2N sodium hydroxide were reacted. The mixture was stirred over-night at about 60° C. and the medium was cooled to ambient temperature, acidified with glacial acetic acid, decanted, impasted in a solution of 2N hydrochloric acid, separated, dried and crystallized from 50 ml of an ethanol-water 49-1 mixture to obtain 0.220 g of the expected product melting at 255° C.

Workup

  1. customwere reacted
  2. temperaturethe medium was cooled to ambient temperature
  3. customdecanted
  4. customseparated
  5. customdried
  6. customcrystallized from 50 ml of an ethanol-water 49-1 mixture

Sources & evidence

ORD record
ord-7a029892ea1c40e3b9b72364650be1ef
Source dataset
uspto-grants-1999_12
Patent number
US06004979

Reaction notes

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