2-Chloro-5-(trifluoromethyl)pyrimidine → (+/-)-cis-(5-(4-Fluorophenyl)-2-methylthiazol-4-yl)(3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-5-(trifluoromethyl)pyrimidine	HCID 13317019	—
Reactant	((2S,3S)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	HCID 89748274	—
Product	(+/-)-cis-(5-(4-Fluorophenyl)-2-methylthiazol-4-yl)(3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone	HCID 131737163	—

Reaction Steps

The title compound was prepared following the same general protocol as described for Example A1 using ((2S,3S)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone and 2-chloro-5-(trifluoromethyl)pyrimidine. ESI-MS (m/z): 494 [M+1]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09440982B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-5f6a3e31d6bf4385b48c7cafa18d589f
Source note	uspto-grants-2016_09