HCID 53882425, compound → HCID 19595122, compound

Participants

Reaction Steps

A mixture of 6-benzyloxy-3,4-dihydro-1H-isoquinoline-2-yl-N-methyl-4-pyridinylamine (5.1 g) and 5% palladium-on-carbon (1.0 g) in methanol (75 ml) was shaken on a Parr hydrogenation apparatus at ambient temperature and an initial pressure of 55 psi for 2 hrs. An additional 1 g of catalyst was added, and the mixture was shaken for an additional 4 hrs at an initial pressure of 55 psi. The reaction mixture was filtered through a pad of celite, the pad was washed with methanol, and the filtrate was concentrated to give 3.45 g (92%) of product. Recrystallization from methanol provided the analytical sample, mp 263-266° C.

Provenance & Evidence