2-Chloro-5-(trifluoromethyl)pyrimidine → (2-(2H-1,2,3-Triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-5-(trifluoromethyl)pyrimidine	HCID 13317019	—
Reactant	(2-(2H-1,2,3-Triazol-2-yl)phenyl)((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)methanone	HCID 117728162	—
Product	(2-(2H-1,2,3-Triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone	HCID 117728133	—

Reaction Steps

The title compound was prepared following the same general protocol as described for Example A1 using (2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)methanone and 2-chloro-5-(trifluoromethyl)pyrimidine. ESI-MS (m/z): 446 [M+1]. 1H NMR (300 MHz, DMSO-d6) δ 8.75-6.80 (m, 9H), 4.95-2.80 (m, 5H), 1.80-0.50 (m, 8H); ESI MS (M+H) 446.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09440982B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-ceced8a148164769b0cfda75e8eefcaf
Source note	uspto-grants-2016_09