Dichloromethane → HCID 19595317, compound

Participants

Reaction Steps

To a solution of (5-fluoro-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-pyridin-4-yl-amine (4.82 g) and dichloromethane (100 ml) at -78° C., boron tribromide (5.5 ml) was added, with stirring. The reaction mixture was warmed to ambient temperature, stirred for 3 hrs, and methanol (100 ml) was added. The mixture was stirred for 1 hr and concentrated in vacuo. The residue was recrystallized from 2-propanol to yield 4.45 g (74%) of product, mp 266° C.

Provenance & Evidence