Sodium Hydroxide → HCID 19595579, compound

Participants

Reaction Conditions

Reaction Steps

1 g (0.0045 mole) of ethyl (Z)-3-[3-[1-(4-chlorophenyl)-1-[4-(methylsulphonyl)phenyl]methylene]-2-oxo-pyrrolidin-1-yl]propanoate are placed in a solution in a mixture of 15 ml of ethanol and 20 ml of water and treated with 0.28 g (1.5 eq.) of sodium hydroxide. The medium is heated at 50° C. for 4 h. The ethanol was evaporated off and the aqueous phase is then extracted with ethyl acetate, acidified with a dilute hydrochloric acid solution, and extracted with dichloromethane. The organic phase is washed with water dried and concentrated. The residue is taken up into t-butyl methyl ether. 1.6 g of (Z)-3-[3-[1-(4-chlorophenyl)-1-[4-(methylsulphonyl)phenyl]methylene]-2-oxo-pyrrolidin-1-yl]propanoic acid are thus obtained as a beige solid of melting point 178-179° C.

Provenance & Evidence