反应详情

温度

70 °C

A mixture of 80 g of hippuric acid and 400 ml of acetic anhydride is heated at 70° C. for two hours. The solution is then brought to ambient temperature and the acetic anhydride is evaporated off under vacuum. The residue is taken up into petroleum ether and crystallises. The crystals are filtered off with suction and washed with petroleum ether and with ethanol to give 25 g of 2-phenyl-5-oxazolone as crystals of melting point 90° C.

1. customis then brought to ambient temperature
2. customthe acetic anhydride is evaporated off under vacuum
3. customcrystallises
4. filtrationThe crystals are filtered off with suction
5. washwashed with petroleum ether and with ethanol