Acetic Anhydride → HCID 15382329, compound

HRID 612525Notes

Reaction equation

HRID 612525 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH3:8][O:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14](=[O:19])[CH:13]2[CH2:20][CH2:21][NH:22][C:23](=[O:25])[CH3:24]>C1C=CC=CC=1>[C:1]([N:15]1[C:16]2[C:12](=[CH:11][C:10]([O:9][CH3:8])=[CH:18][CH:17]=2)[CH:13]([CH2:20][CH2:21][NH:22][C:23](=[O:25])[CH3:24])[C:14]1=[O:19])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 9859734HCID 9859734, compound

Product 1

HCID 15382329HCID 15382329, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

Acetic anhydride (0.5 ml) is added with stirring to N-[2-(5-methoxy-2-oxo-2,3-dihydroindol-3-yl)ethyl]-acetamide (120 mg) dissolved in benzene (5 ml). The mixture is heated for 1 h in refluxing benzene. The solvent is evaporated off and the crude product is separated on a silica plate. N-[2-(1-acetyl-2-oxo-5-methoxyindol-3-yl)ethyl]acetamide (6) is thus obtained.

Workup

  1. temperatureThe mixture is heated for 1 h
  2. customThe solvent is evaporated off
  3. customthe crude product is separated on a silica plate

Sources & evidence

ORD record
ord-714a0bab5a3e4e6d83d2e22ff04450ed
Source dataset
uspto-grants-1999_12
Patent number
US06004991

Reaction notes

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