Diethylaminoethyl chloride → HCID 19594742, compound

Participants

Reaction Steps

In a manner analogous to Example 3D1, prepare a solution of 1,5-dihydroxy-fluoren-9-one (0.5 g, 2.3 mmole) in 4 mL of methanol and 12 mL chlorobenzene, then add the sodium methoxide (0.28 g, 5.1 mmole). The free base 2-chloro-ethyl-diethyl amine is added (1.1 g, 6 mmole) in 20 mL chlorobenzene. Work-up the reaction in the usual manner to obtain the title compound. m.p. 180-184° C. (dec.). Yield 0.68 g, 61%.

Provenance & Evidence