2-Chloro-5-(trifluoromethyl)pyridine → HCID 117727831, compound

HRID 61259Notes

Reaction equation

HRID 61259 reaction equation
[F:1][C:2]1[C:3]([N:12]2[N:16]=[CH:15][CH:14]=[N:13]2)=[C:4]([C:8]([F:11])=[CH:9][CH:10]=1)[C:5]([OH:7])=O.[CH3:17][C@@H:18]1[CH2:23][CH2:22][CH2:21][NH:20][C@@H:19]1[CH2:24][N:25]1C(=O)C2C(=CC=CC=2)C1=O.Cl[C:37]1[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][N:38]=1>>[F:1][C:2]1[C:3]([N:12]2[N:16]=[CH:15][CH:14]=[N:13]2)=[C:4]([C:5]([N:20]2[CH2:21][CH2:22][CH2:23][C@@H:18]([CH3:17])[C@H:19]2[CH2:24][NH:25][C:37]2[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][N:38]=2)=[O:7])[C:8]([F:11])=[CH:9][CH:10]=1

Participants

4

Reactant 3

HCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 1177276302-(((2S,3R)-3-Methylpiperidin-2-yl)methyl)isoindoline-1,3-dioneHCID 117727942HCID 117727942, compound

Product 1

HCID 117727831HCID 117727831, compound

Procedure

The title compound was prepared from 3,6-difluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid, 2-(((2S,3R)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione, and 2-chloro-5-(trifluoromethyl)pyridine using the methods described herein. ESI-MS (m/z): 481 (M+H).

Sources & evidence

ORD record
ord-6d2a64c977a4447c9f33c438f284c730
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

Loading…