Diisopropylamine → HCID 19594890, compound

Participants

Reaction Conditions

Reaction Steps

Similar to Example 7C prepare the LDA reagent by adding dropwise n-butyl lithium (8.2 mL, 21 mmole of 2.5 M) to diisopropyl amine (2.0 g, 2.8 mL/d=0.722, 20.3 mmol) at -50° C. in 50 mL tetrahydrofuran (THF) under argon. Allow reaction to warm to 0° C. then dropwise add N,N-diethyl-6-isopropoxy-2',4'-dimethoxy-biphenyl-2-carboxamide (3.0 g, 8.1 mmole) in 50 mL THF. Allow reaction to further warm to room temperature and stir overnight. Continue procedure from Example 7C to obtain 2.0 g (6.7 mmole, 83%) of the title compound. (EtOAc/hexane 4:6, Rf=0.50)

Provenance & Evidence