2-Fluoro-5-(trifluoromethyl)pyridine → (2-Fluoro-3-methoxy-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone

Participants

Reaction Steps

The title compound was prepared following the same general protocol as described in Example A1, using 2-fluoro-3-methoxy-6-(2H-1,2,3-triazol-2-yl)benzoic acid, 2-(((2S,3R)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione and 2-fluoro-5-(trifluoromethyl)pyridine. ESI-MS (m/z): 493 [M+1]+. 1H NMR (500 MHz, DMSO-d6) δ 8.40-6.45 (m, 8H), 4.85-2.70 (m, 8H), 1.85-0.65 (m, 8H).

Provenance & Evidence