Water → 5-Fluoro-3-methyl-2-nitrobenzoic acid

HRID 61266Notes

Reaction equation

HRID 61266 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5]([OH:7])=[O:6].[N+:12]([O-])([O-:14])=[O:13].[K+].O>OS(O)(=O)=O>[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:8]([N+:12]([O-:14])=[O:13])=[C:4]([CH:3]=1)[C:5]([OH:7])=[O:6]

Participants

5

Reactant 3

HCID 962WaterHCID 24434Potassium NitrateHCID 27784473-Fluoro-5-methylbenzoic acid

Product 1

HCID 534307765-Fluoro-3-methyl-2-nitrobenzoic acid

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

3-Fluoro-5-methylbenzoic acid (4 g, 25.96 mmol) and KNO3 (2.884 g, 28.556 mmol) were dissolved in conc. H2SO4 (32 mL) at 0° C. The mixture was stirred at rt for 1 h. Water (60 mL) was added, and the resulting precipitate was filtered and dried to provide the title compound, which was used without further purification.

Workup

  1. filtrationthe resulting precipitate was filtered
  2. customdried

Sources & evidence

ORD record
ord-4d41f93c6fe541ed878f729d252ca1c6
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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