2-Bromophenyl isocyanate → HCID 22011338, compound

HRID 612663Notes

Reaction equation

HRID 612663 reaction equation
[OH:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[Br:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N:17]=[C:18]=[O:19]>>[OH:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH:4][C:18]([NH:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[Br:10])=[O:19]

Participants

3

Reactant 2

HCID 1370972-Bromophenyl isocyanateHCID 1857632-Amino-5-fluorophenol

Product 1

HCID 22011338HCID 22011338, compound

Procedure

The urea was prepared from 2-hydroxy 4-fluoro aniline (254 mg, 2 mmol) and 2-bromo phenyl isocyanate by general Method B. It was purified by dilution with methylene chloride and precipitation with hexane (173 mg. 26%). EI-MS m/z 325 (M+H)+

Workup

  1. customIt was purified by dilution with methylene chloride and precipitation with hexane (173 mg. 26%)

Sources & evidence

ORD record
ord-c1f3b6b4bed54605b22a4091cd3e3e12
Source dataset
uspto-grants-1999_12
Patent number
US06005008

Reaction notes

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