3-Aminosalicylic acid → (2-Bromophenyl)urea

HRID 612669Notes

Reaction equation

HRID 612669 reaction equation
OC1C([NH2:11])=CC=CC=1C(O)=O.[Br:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]=[C:20]=[O:21]>>[Br:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH:19][C:20](=[O:21])[NH2:11]

Participants

3

Reactant 2

HCID 684433-Aminosalicylic acidHCID 1370972-Bromophenyl isocyanate

Product 1

HCID 139386(2-Bromophenyl)urea

Procedure

The urea was prepared from 2-hydroxy 3-amino benzoic acid (300 mg, 2 mmol) and 2-bromo phenyl isocyanate by general Method B. It was purified by dilution of the DMF solution with methylene chloride and precipitation with hexane (0.287 g. 41%). EI-MS m/z 351 (M+H)+

Workup

  1. customIt was purified by dilution of the DMF solution with methylene chloride and precipitation with hexane (0.287 g. 41%)

Sources & evidence

ORD record
ord-c16e054c3632477183b5d81845715f7a
Source dataset
uspto-grants-1999_12
Patent number
US06005008

Reaction notes

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