3-Fluoro-2-methylaniline → 4-Fluoro-2-iodo-3-methylbenzoic acid
Reaction equation
F[C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([I:11])[C:5]([CH3:12])=[CH:4][CH:3]=1.[F:13]C1C(C)=C(C=CC=1)N>>[F:13][C:4]1[CH:3]=[CH:2][C:7]([C:8]([OH:10])=[O:9])=[C:6]([I:11])[C:5]=1[CH3:12]Participants
3
Procedure
The title compound was prepared following the same general protocol as described for 6-fluoro-2-iodo-3-methylbenzoic acid in Example A352 using 3-fluoro-2-methylaniline. MS (ESI) 281 (M+H).
Sources & evidence
- ORD record
- ord-881a9ce23cfe45aeb006dae186b43be1
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09440982B2
Reaction notes
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