Ethanol → Ethyl 2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]-3-(ethylthioureido)benzoate

Participants

Reaction Steps

A mixture of ethyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)-methyl]amino]benzoate (1.61 g), ethyl isothiocyanate (1.5 ml) and ethanol (1 ml) was stirred at room temperature for 3 days. The reaction mixture was dissolved in ethyl acetate and the solution was washed with water, dried and concentrated to dryness to give crystals. Recrystallization from ethyl acetate--hexane afforded pale yellow crystals (1.92 g, 91%), m.p. 108-110° C.

Provenance & Evidence