6-fluoro-3-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid → 5-Fluoro-4-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid

HRID 61278Notes

Reaction equation

HRID 61278 reaction equation
FC1C(C(O)=O)=C([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)C(C)=CC=1.[F:17][C:18]1[C:19]([CH3:28])=[CH:20][C:21](I)=[C:22]([CH:26]=1)[C:23]([OH:25])=[O:24]>>[F:17][C:18]1[C:19]([CH3:28])=[CH:20][C:21]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:22]([CH:26]=1)[C:23]([OH:25])=[O:24]

Participants

3

Reactant 2

HCID 1177276806-fluoro-3-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acidHCID 1177277945-Fluoro-2-iodo-4-methylbenzoic acid

Product 1

HCID 1177282025-Fluoro-4-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid

Procedure

The title compound was prepared following the same general protocol as described for 6-fluoro-3-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid in Example A352 using 5-fluoro-2-iodo-4-methylbenzoic acid. MS (ESI) 222 (M+H).

Sources & evidence

ORD record
ord-65f38278d9e9450bafaf930eb900bde1
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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