Sodium Hydroxide → HCID 178460782, compound

Participants

Reaction Steps

A solution of ethyl 2-propylthio-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate (0.25 g) in methanol (5 ml) containing 1N-NaOH (1.5 ml) was heated under reflux for 2 hours. After removal of the solvent, the aqueous residue was adjusted to about pH 3-4 with 1N-HCl to give crystals. The crystals were collected by filtration. Recrystallization from ethyl acetate--hexane gave colorless crystals (0.21 g, 91%), m.p. 222-223° C. (decomp.).

Provenance & Evidence