Methyl 2-ethoxy-1-[[2′-(methoxycarbonyl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate → HCID 22596780, compound

HRID 612791Notes

Reaction equation

[CH2:1]([O:3][C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]([O:24]C)=[O:23])=[CH:12][CH:11]=2)[C:7]2[C:26]([C:30]([O:32]C)=[O:31])=[CH:27][CH:28]=[CH:29][C:6]=2[N:5]=1)[CH3:2]>CO>[CH2:1]([O:3][C:4]1[N:8]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]([OH:24])=[O:23])=[CH:14][CH:15]=2)[C:7]2[C:26]([C:30]([OH:32])=[O:31])=[CH:27][CH:28]=[CH:29][C:6]=2[N:5]=1)[CH3:2]

Participants

Conditions

Temperature: 80 °C

Procedure

To a solution of methyl 2-ethoxy-1-[(2'-methoxycarbonylbiphenyl-4-yl)methyl]benzimidazole-7-carboxylate (0.7 g) in methanol (10 ml) was added 1N NAOH (5 ml) and the mixture was stirred at 80° C. for 3 hours. After evaporation of the methanol, the aqueous residue was neutralized with 1N hydrochloric acid to give crystals. The crystals were recrystallized from methanol--chloroform to afford colorless crystals (0.54 g, 83%), m.p. 213-215° C.

Workup

customAfter evaporation of the methanol
customto give crystals
customThe crystals were recrystallized from methanol

Sources & evidence

ORD record: ord-d9b25ee06c7f4343a481a44b188ce0d1
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06004989

Reaction notes

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