HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoropyridine → HCID 10825211, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoropyridine | HCID 9746 | — |
| Reactant | Trimethyltin chloride | HCID 14016 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 10825211 | HCID 10825211 | — |
Reaction Steps
Metalation of 2-fluoropyridine was performed as described in Estel, Marsais and Queguiner, J. Org. Chem. 53, 2740-2744, 1988. The lithium anion was quenched with 1 eq. of trimethyl tin chloride in THF (1M) at -78° C. and stirred for 30', quenched with 1M sodium bicarbonate and extracted with ethyl acetate. Upon Na2SO4 drying and evaporation under reduced pressure the resulting oil was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06005096 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-b85ef96c3a2645b8a31fc38a3993dde9 |
| Source note | uspto-grants-1999_12 |