Tributylvinyltin → HCID 9840745, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2',3'-di-O-acetyl-5'-deoxy-5-iodocytidine, (1.6 g, 3.66 mmol) in 10 ml DMF were added Pd2 (dba)3 (67 mg, 0.073 mmol) and tri-2-furylphosphine (85 mg, 0.366 mmol) and tri-n-butyl(vinyl)stannane (2.1 ml, 7.318 mmol) under Ar atmosphere at room temperature. After stirring for 19 h, tri-n-butyl(vinyl)stannane (2.1 ml, 7.318 mmol ) was added to the reaction mixture, which was then warmed up to 40° C. with stirring for 24 hours. The solvent was removed in vacuo, and the residue purified by silica gel column chromatography (eluent: ethyl acetate~CH2Cl2 : MeOH=95: 5) to give 2',3'-di-O-acetyl-5'-deoxy-5-vinylcytidine (1.13 g, 92%) as a colorless solid:

Provenance & Evidence