Bromine → 4'-Benzyloxy-2-bromopropiophenone

HRID 612819Notes

Reaction equation

HRID 612819 reaction equation
[CH3:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)=[O:4].[Br:19]Br>C(O)(=O)C>[CH2:12]([O:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH:2]([Br:19])[CH3:1])=[CH:6][CH:7]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 78246p-Benzyloxypropiophenone

Product 1

HCID 1000404'-Benzyloxy-2-bromopropiophenone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Scheme X depicts the bromination of 4-benzyloxypropiophenone in acetic acid with bromine to yield 4'-(benzyloxy)-2-bromopropiophenone. When this reaction is complete, the mixture can be quenched with water. The resulting precipitate can be collected, washed with dilute acetic acid, water and heptane, and dried. ##STR38##

Sources & evidence

ORD record
ord-55a76be278f840318ece4b36151bf241
Source dataset
uspto-grants-1999_12
Patent number
US06005102

Reaction notes

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