2-Chloro-5-(trifluoromethyl)pyridine → HCID 117727840, compound

HRID 61283Notes

Reaction equation

HRID 61283 reaction equation
[F:1][C:2]1[C:3]([N:12]2[N:16]=[CH:15][CH:14]=[N:13]2)=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5]([OH:7])=O.[CH3:17][C@@H:18]1[CH2:23][CH2:22][CH2:21][NH:20][C@@H:19]1[CH2:24][N:25]1C(=O)C2C(=CC=CC=2)C1=O.Cl[C:37]1[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][N:38]=1>>[F:1][C:2]1[C:3]([N:12]2[N:16]=[CH:15][CH:14]=[N:13]2)=[C:4]([C:5]([N:20]2[CH2:21][CH2:22][CH2:23][C@@H:18]([CH3:17])[C@H:19]2[CH2:24][NH:25][C:37]2[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][N:38]=2)=[O:7])[CH:8]=[C:9]([CH3:11])[CH:10]=1

Participants

4

Reactant 3

HCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 1177276302-(((2S,3R)-3-Methylpiperidin-2-yl)methyl)isoindoline-1,3-dioneHCID 1177278243-Fluoro-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid

Product 1

HCID 117727840HCID 117727840, compound

Procedure

The title compound was prepared following the same general protocol as described in Example A318, using 3-fluoro-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, 2-(((2S,3R)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione and 2-chloro-5-(trifluoromethyl)pyridine. ESI-MS (m/z): 477 (M+H).

Sources & evidence

ORD record
ord-89778a735eab4e3ea2cb4e176cc8434b
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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