反应详情

A process for preparing Form A of N-[[[2-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-benzenesulfonamide of claim 1 which comprises reacting [4-[[(2-aminoethyl)thio]methyl]-2-thiazolyl]guanidine dihydrochloride with ethyl 4-bromo-benzene-sulfonylformimidate formimidate in methanol and in the presence of potassium hydroxide, followed by filtering and adding isopropanol over the filtrate to obtain N-[[[2-[[[2-(diaminomethylene)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-benzenesulfonamide isopropanolate dissolving in methanol, filtering, and adding to water.

1. filtrationby filtering
2. additionadding isopropanol over the filtrate