Potassium Hydroxide → HCID 86754978, compound

HRID 612841Notes

Reaction equation

HRID 612841 reaction equation
NC(=NC1S[CH:7]=[C:8]([CH2:10]SCCNC=[N:16][S:17]([C:20]2[CH:25]=[CH:24][C:23]([Br:26])=[CH:22][CH:21]=2)(=[O:19])=[O:18])N=1)N.Cl.Cl.NCCSCC1N=C(NC(N)=N)SC=1.C(=N)[OH:44].BrC1C=CC(S(C(=N)OCC)(=O)=O)=CC=1.[OH-].[K+]>CO>[CH:8]([O-:44])([CH3:10])[CH3:7].[Br:26][C:23]1[CH:22]=[CH:21][C:20]([S:17]([NH2:16])(=[O:18])=[O:19])=[CH:25][CH:24]=1

Participants

6

Reactant 4

HCID 14797Potassium HydroxideHCID 178468388HCID 178468388, compoundHCID 178478806HCID 178478806, compoundHCID 178512721HCID 178512721, compound

Product 1

HCID 86754978HCID 86754978, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A process for preparing Form A of N-[[[2-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-benzenesulfonamide of claim 1 which comprises reacting [4-[[(2-aminoethyl)thio]methyl]-2-thiazolyl]guanidine dihydrochloride with ethyl 4-bromo-benzene-sulfonylformimidate formimidate in methanol and in the presence of potassium hydroxide, followed by filtering and adding isopropanol over the filtrate to obtain N-[[[2-[[[2-(diaminomethylene)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-benzenesulfonamide isopropanolate dissolving in methanol, filtering, and adding to water.

Workup

  1. filtrationby filtering
  2. additionadding isopropanol over the filtrate

Sources & evidence

ORD record
ord-ee9eab03a4e24b6692cdca3a8ddb2891
Source dataset
uspto-grants-1999_12
Patent number
US06005115

Reaction notes

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