3-(2-(N-tert-butoxycarbonylamino)ethoxy)-5-phenylisoxazole → 3-(2-Aminoethoxy)-5-phenylisoxazole hydrochloride

HRID 612857Notes

Reaction equation

HRID 612857 reaction equation
[ClH:1].O1CCOCC1.C(OC([NH:15][CH2:16][CH2:17][O:18][C:19]1[CH:23]=[C:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[O:21][N:20]=1)=O)(C)(C)C>>[ClH:1].[NH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:23]=[C:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[O:21][N:20]=1

Participants

3

Reactant 2

HCID 154349603-(2-(N-tert-butoxycarbonylamino)ethoxy)-5-phenylisoxazoleHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 98595963-(2-Aminoethoxy)-5-phenylisoxazole hydrochlorideYield 99%

Procedure

A solution of 4N hydrochloric acid/1,4-dioxane (4.0 ml) was added to 3-(2-(N-tert-butoxycarbonylamino)ethoxy)-5-phenylisoxazole (0.50 g), and the mixture was stirred at room temperature for 15 minutes. The precipitate was separated from the mixture by filtration and washed with ethyl acetate to obtain the title compound (0.39 g, 99%) as colorless crystals.

Workup

  1. customThe precipitate was separated from the mixture by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-c46849b2fb8e45e693db535177303647
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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