tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596710, compound

HRID 612858Notes

Reaction equation

HRID 612858 reaction equation
[Cl:1][C:2]1[C:3]([OH:13])=[N:4][O:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23]O)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([NH:21][CH2:22][CH2:23][O:13][C:3]1[C:2]([Cl:1])=[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[O:5][N:4]=1)=[O:20])([CH3:17])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178519000HCID 178519000, compound

Product 1

HCID 19596710HCID 19596710, compoundYield 72.7%

Procedure

4-Chloro-3-hydroxy-5-phenylisoxazole (0.58 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.48 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 1 (a) to obtain the title compound (0.73 g, 72%) as colorless crystals.

Sources & evidence

ORD record
ord-41eef13d6e884e65b49a4976ccbcd0de
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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